"Bahaya Imunisasi?" Telaah Tahap II

Nilsson L, Kjellman NI, Bjorksten B. A randomized controlled trial of the effect of pertussis vaccines on atopic disease. Arch Pediatr Adolesc Med 1998 Aug;152(8):734-8 (http://archpedi.ama-assn.org/cgi/reprint/152/8/734.pdf)

--> Conclusion: We found no support for a drastic increase in allergic manifestations after pertussis vaccination. There was a positive association between whooping cough and asthma by 2 1/2 years of age. There seems to be little reason to withhold pertussis vaccination from infants, irrespective of family history of allergy.

Karvonen M, Cepaitis Z, Tuomilehto J.Association between type 1 diabetes and Haemophilus influenzae type b vaccination: birth cohort study.  BMJ1999;318:1169 (http://www.bmj.com/content/318/7192/1169)

--> Conclusion: It is unlikely that H influenzae type b vaccination or its timing cause type 1 diabetes in children.

Hiltunen M, Lönnrot M, Hyöty H. Immunisation and Type 1 Diabetes Mellitus: Is There a Link? Drug Saf. 1999 Mar;20(3):207-12.

--> Conclusion: there is no clear evidence that any currently used vaccine can prevent or induce diabetes in humans

Graves PM, Barriga KJ, Norris JM, Hoffman MR, Yu L, Eisenbarth GS, Rewers M. Lack of association between early childhood immunizations and beta-cell autoimmunity. Diabetes Care. 1999 Oct;22(10):1694-7.(http://care.diabetesjournals.org/content/22/10/1694.full.pdf)

--> Conclusion: The results suggest that changing the early childhood immunization schedule would not affect the risk of developing beta-cell autoimmunity or type 1 diabetes.

Ryan EJ, Nilsson L, Kjellman N, Gothefors L, Mills KH. Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE responses against pertussis toxin but not against common allergens.  Clin Exp Immunol. 2000 Aug;121(2):193-200.(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905694/?tool=pubmed)

--> Conclusion: despite the enhancement of type-2 responses to B. pertussis antigens, booster vaccination with Acellular pertussis vaccines (Pa) does not appear to be a risk factor for allergy.

DeStefano F, Mullooly JP, Okoro CA, Chen RT, Marcy SM, Ward JI, Vadheim CM, Black SB, Shinefield HR, Davis RL, Bohlke K; Vaccine Safety Datalink Team. Childhood vaccinations, vaccination timing, and risk of type 1 diabetes mellitus.Pediatrics. 2001 Dec;108(6):E112.