Perlu dicatat bahwa asupan vitamin D yang berlebih, baik karena asupan vitamin D yang berkepanjangan atau dosis tambahan yang berlebihan, dapat menyebabkan hiperkalsemia dan/atau hiperkalsiuria. Studi kasus menunjukkan bahwa suplemen vitamin D 50.000-300.000 IU/hari dapat menyebabkan hiperkalsemia dalam beberapa minggu. Â
Referensi
Cashman, K. D. (2020). Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. In Calcified Tissue International (Vol. 106, Issue 1, pp. 14--29). Springer. https://doi.org/10.1007/s00223-019-00559-4
Charoenngam, N., & Holick, M. F. (2020). Immunologic effects of vitamin d on human health and disease. In Nutrients (Vol. 12, Issue 7, pp. 1--28). MDPI AG. https://doi.org/10.3390/nu12072097
K. Coussens, A. (2011). Immunomodulatory Actions of Vitamin D Metabolites and their Potential Relevance to Human Lung Disease. Current Respiratory Medicine Reviews, 7(6), 444--453. https://doi.org/10.2174/157339811798072577
Remelli, F., Vitali, A., Zurlo, A., & Volpato, S. (2019). Vitamin D deficiency and sarcopenia in older persons. In Nutrients (Vol. 11, Issue 12). MDPI AG. https://doi.org/10.3390/nu11122861
Roth, D. E., Abrams, S. A., Aloia, J., Bergeron, G., Bourassa, M. W., Brown, K. H., Calvo, M. S., Cashman, K. D., Combs, G., De-Regil, L. M., Jefferds, M. E., Jones, K. S., Kapner, H., Martineau, A. R., Neufeld, L. M., Schleicher, R. L., Thacher, T. D., & Whiting, S. J. (2018). Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low-and middle-income countries. Annals of the New York Academy of Sciences, 1430(1), 44--79. https://doi.org/10.1111/nyas.13968
Wimalawansa, S. J. (2019). Vitamin D deficiency: Effects on oxidative stress, epigenetics, gene regulation, and aging. In Biology (Vol. 8, Issue 2). MDPI AG. https://doi.org/10.3390/biology8020030
Zhou, Y. F., Luo, B. A., Qin, L. L., & Shidoji, Y. (2019). The association between Vitamin D deficiency and community-acquired pneumonia: A meta-analysis of observational studies. Medicine (United States), 98(38). https://doi.org/10.1097/MD.0000000000017252
Baca konten-konten menarik Kompasiana langsung dari smartphone kamu. Follow channel WhatsApp Kompasiana sekarang di sini: https://whatsapp.com/channel/0029VaYjYaL4Spk7WflFYJ2H