Propylene Glycol is a common solvent that is better than glycerin and dissolves a variety of ingredients such as phenols, sulfonamides, vitamins (A and D), and most steroids. Propylene Glycol has a hydrophilic group structure that can make it easier for Propylene Glycol to mix with water. Propylene Glycol is alkaline with a pH> 7.5.
This substance is a commonly used excipient in gel formulations. It is commonly used as a penetration enhancer, co-solvent, and humectant. The use of different compositions of gelling agents and humectants in the formulation of gel formulations can affect the physical properties and stability of gel formulations.
Propylene Glycol provides the greatest increase in flux value compared to other penetrators. Propylene Glycol softens the stratum corneum in the skin and moisturizes the skin. This facilitates the penetration and diffusion of the drug substance through the cell membrane.
The stratum corneum is located at the outermost layer of the skin, the main barrier is the stratum corneum that prevents drugs or products from penetrating the epidermis. To reach the stratum corneum in order to enter the target tissue layer in an active form, and remain attached to the skin for a long time, antioxidants as a skin barrier must be able to reach it.
Due to its high water content, the gel moisturizes the skin layer (stratum corneum) and enhances the penetration of drug delivery. Compared to ointments, cream formulations, and other formulations. Gel formulations have better spreadability, easier to rinse off, more elegant appearance, and have higher penetration into the skin with the help of penetration enhancers.
The use of penetration enhancers is a method used to increase the rate of penetration of chemical compounds into the tissue layer and fight free radicals to prevent premature aging. Drug diffusion helps increase penetration by denaturing skin proteins or dissolving the active ingredients in the skin through the stratum corneum. One of the penetration enhancers is Propylene Glycol.
The organic compound, namely Propylene Glycol, is commonly used in various applications such as in cosmetics, industry, pharmaceuticals, and food additives. It is commonly used as an emulsifier, thickener, solvent, and stabilizer.
In the pharmaceutical industries and chemical, Propylene Glycol is commonly used as an additive, such as: Coolants, Anti-freeze, Plasticizers, Heat Transfer and Hydraulic Fluids. Looking at its use in the industries mentioned above, it is understandable that many people are concerned about the use of Propylene Glycol on the face and skin in skincare products.
According to certified dermatologist Dr. Jennifer Herman, Propylene Glycol is a moisturizer in the form of a clear liquid, colorless, thick, virtually odorless, sweet-tasting, and, like glycerin, quite pungent. By adding water to propylene oxide, which is obtained from petroleum products, the synthetic product Propylene Glycol is created.
Propylene Glycol is often used in topical formulations due to its low irritation and toxicity. Research shows that the higher the concentration of Propylene Glycol used, the higher the permeability of hesperidin gel. Even at 5% Propylene Glycol concentration, it is possible to show increased penetration of pioglitazone into the transdermal patch formulation.
Propylene Glycol In Facial WashÂ
