Long Acting Paliperidone Injection in Patient with Bipolar Affective Disorder, Current Episode Manic with Psychotic Symptoms

An important determinant of the clinical course in bipolar disorder is adherence or non-adherence to medications, estimated at 10--60 % in these patients even during their euthymic periods. Non adherence to mood stabilizers and antipsychotics in the treatment of bipolar disorder increase the risk of suicide, relapse, and rehospitalization. An alternative to reduce the non-adherence of oral medication is the usage of long acting injectable (LAI) antipsychotic.